Pharmaceutical giant AstraZeneca has said it is buying a US drug company in a deal worth 39 billion US dollars (£29 billion). [33] In October 2013, AstraZeneca announced it would acquire biotech oncology company Spirogen for around US$440 million. Office on AstraZeneca's campus in Waltham, Massachusetts. [43] The company underwrote twenty out of thirty-two seats of a new Cambridge– Gothenburg service by Sun-Air of Scandinavia. The strategic transaction strengthens AstraZeneca’s respiratory franchise globally and builds on the acquisition of Almirall’s respiratory portfolio in 2014 by extending the company’s development and commercialisation rights into the US for both Tudorza Pressair and Duaklir Genuair. London, CB2 0AA [65][66], In October 2019, AstraZeneca announced it would sell the global commercial rights for its drug to treat acid reflux to German pharmaceutical company Cheplapharm Arzneimittel GmbH for as much as US$276 million. We built Mergr to save people the arduous and time-consuming process of tracking when companies are bought, sold, and who currently owns them. [64], In September 2019, the company announced that it would cease drug production at its German headquarters in Wedel, leading to the loss of 175 jobs by the end of 2021. [110] The sum included US$2.3 million in company funds he allegedly used to fix up three of his homes, plus money the company paid as the result of the EEOC investigation. AstraZeneca has acquired in 7 different US states, and 6 countries. [77], On 30 December 2020, the United Kingdom approved the emergency use of AstraZeneca’s Coronavirus Vaccine. United Kingdom, He also noted that the deal is “an important step” in pursuing the company’s vision of a “world free of pain for patients.” [36] In September 2014 the company would join forces with Eli Lilly in developing and commercialising its candidate BACE inhibitor – AZD3292 – used for the treatment of Alzheimer's disease. The transaction would also have been the biggest foreign takeover of a British company. Acquisition to include non-US rights to roflumilast and will be accretive to 2016 earnings, contributing to AstraZeneca’s return to growth strategy. Nonetheless, controversy around the case has continued. Company Participants. [101], It was also announced that Leif Johansson would succeed Louis Schweitzer as non-executive chairman on 1 June 2012, three months earlier than previously announced, and would become Chairman of the Nomination and Governance Committee after the 2012 Annual General Meeting. [74], In December 2020, AstraZeneca announced that it would acquire Alexion Pharmaceuticals in a $39 billion deal. AstraZeneca to acquire MedImmune for $58 per share in a fully recommended, all-cash transaction with a total enterprise value of $15.2 billion Acquisition delivers AstraZeneca … [39] In December, the company received accelerated FDA approval for Olaparib in the treatment of women with advanced ovarian cancer who have a BRCA genetic mutation. E.g. We note that AstraZeneca has a strong presence in oncology, cardiovascular, renal … Facebook, Microsoft, Zillow. The acquisition is expected to close in the third quarter of 2021. Timeline Acquisition - AstraZeneca Investor Presentation. The following is an illustration of the company's major mergers and acquisitions and historical predecessors: [60] In 2017, it was the eleventh largest drug company in the world based on sales and ranked seventh based on R&D investment. Astrazeneca’s $15.6bn acquisition of Medimmune in 2007 marked the last lavish biotech takeover of the previous cycle. 1 Francis Crick Avenue Cambridge Biomedical Campus, Today, AstraZeneca employs 70,600 people (as of 2019) in over 100 countries around the world. It is the biggest deal in AstraZeneca’s history and will be the largest acquisition in pharmaceuticals since AbbVie bought Allergan for more than US$63bn in 2019. ", "Covid-19: Oxford-AstraZeneca coronavirus vaccine approved for use in UK", "India's Covid vaccine hope rolls over to 2021; panel to meet again on Jan 1", "Coronavirus: AstraZeneca donates nine million face masks and steps up Covid-19 drugs research", "UK coronavirus testing capacity boosted by new AstraZeneca, GSK lab", "Cambridge-based AstraZeneca to test one of its cancer medicines for Covid-19 patients | Anglia - ITV News", "Final testing stage for potential coronavirus vaccine set to begin in July", "A Phase III study to investigate a vaccine against COVID-19", "Why AstraZeneca Covid-19 vaccine approval 'good news for whole world'? [84] One of them, AZD1222, reached phase III trials. [24], In February 2012, AstraZeneca and Amgen announced a collaboration on treatments for inflammatory diseases. List of AstraZeneca 's 13 Acquisitions, including Alexion Pharmaceuticals and Takeda Respiratory Business. Companies People Investors Funding Rounds Acquisitions Schools Events Hubs Saved . The primary uses are treatment of gastroesophageal reflux disease, treatment and maintenance of erosive esophagitis, treatment of duodenal ulcers caused by Helicobacter pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and treatment of gastrointestinal ulcers associated with Crohn's disease. AstraZeneca was founded in 1992 and is based in Cambridge, the United Kingdom. AstraZeneca announced today the successful completion of the tender offer for all of the outstanding shares of ZS Pharma (NASDAQ: ZSPH) and the subsequent acquisition of ZS Pharma as previously announced in November. [45] Towards the end of April the company announced a number of collaborations worth an estimated US$1.8 billion; first, to develop and commercialise MEDI4736, with Celgene, for use against non-Hodgkin’s lymphoma, myelodysplastic syndromes, and multiple myeloma with AstraZeneca receiving US$450 million. [41] Later in the same month the company announced it would partner with Orca Pharmaceuticals to develop retinoic acid-related orphan nuclear receptor gamma inhibitors for use in the treatment of a number of autoimmune diseases, which could generate up to US$122.5 million for Orca. AstraZeneca was on the hunt for acquisitions earlier this year and made a preliminary approach to Gilead Sciences Inc., Bloomberg reported in June. [76], On 27 December 2020, the AstraZeneca chief Pascal Soriot said that they have “figured out the winning formula” with their two-dose system with the Oxford University’s COVID-19 vaccine. [25] Then in April 2012, AstraZeneca acquired Ardea Biosciences, another biotechnology company, for $1.26 billion. The largest deal in AstraZeneca’s history has the market concerned that the company is paying too much for Alexion, even as analysts have praised the assets and drugs it will pull into its pipeline. Acquisition history. AstraZeneca - Small Molecule Anti-Infective Business, M&A research that takes seconds (not all afternoon), Better understand your customers and prospects. LONDON/NEW YORK (Reuters Breakingviews) - The largest acquisition in AstraZeneca’s history is bold as well as big. For AstraZeneca, the acquisition is a major shift, catapulting the British pharma giant to the upper ranks of rare disease drugmaking. [78][79][80], In March 2020, the company announced that it would be donating PPEs, including 9 million face masks, to help support various international health organisations mitigating the COVID-19 pandemic. Operator. The deal on the drug known as trastuzumab deruxtecan sent shares in Japan's Daiichi soaring 16%. University of Minnesota Professor of Bioethics Carl Elliott noted that Markingson was enrolled in the study against the wishes of his mother, Mary Weiss, and that he was forced to choose between enrolling in the study or being involuntarily committed to a state mental institution. [5] AstraZeneca has a portfolio of products for major diseases including oncology, cardiovascular, gastrointestinal, infection, neuroscience, respiratory and inflammation areas. In the sale to AstraZeneca, holders of each Alexion share will receive $60 in cash and 2.1243 AstraZeneca American depositary shares, the U.K. company said in a press release Saturday. AstraZeneca Plc agreed to buy Alexion Pharmaceuticals Inc. for $39 billion in cash and shares, adding a specialist in the treatment of rare diseases and … [95], AstraZeneca has its corporate headquarters in Cambridge, United Kingdom, and its main research and development (R&D) centers are in Cambridge (UK), Gaithersburg (Maryland, US), Gothenburg (Sweden) and Warsaw (Poland). [58], In July 2017, the company's CEO Pascal Soriot said that Brexit would not affect its commitment to its current plans in the United Kingdom. [61] In January EVP Pam Cheng stated that AstraZeneca has ignited startup of duplicate QA testing facility in Sweden and has initiated hiring in Sweden. In 2014, AstraZeneca were themselves almost acquired by rivals Pfizer in a deal worth $118 billion USD. [88], On 29 January 2021, the European Medicines Agency (EMA) recommended granting a conditional marketing authorisation for AZD1222 in people from 18 years of age. After series of small acquisitions, AZ announced its first billion dollar acquisition of Cambridge Antibody Technology in the year 2004. The drugmaker will fund the acquisition with a $17.5 billion financing facility from Morgan Stanley, JPMorgan Chase & Co. and Goldman Sachs Group Inc. The Company is unable to provide guidance and indications on a Reported basis because AstraZeneca cannot reliably forecast material elements of the Reported result, including any fair-value adjustments arising on acquisition-related liabilities, intangible-asset impairment charges and legal-settlement provisions. We have a team of expert recruiters in our Talent Acquisition team who are ready to pick up your application. AstraZeneca is borrowing $17.5 billion to fund the acquisition. AstraZeneca fended off … AstraZeneca plans to use some of the proceeds of a US$3.5 billion share issue to fund the deal. [13], In 2005, the company acquired KuDOS Pharmaceuticals, a UK biotech company, for £120 million. In the year 1999 Astra and Zeneca Group merged to form AstraZeneca (AZ). December 12, 2020. [37] In November 2014 the company's biologics R&D operation, MedImmune, agreed to acquire Definiens for more than US$150 million. Executive Director and Chief Executive Officer. [27][28] It was agreed that Bristol Myers Squibb would acquire Amylin for $5.3 billion in cash and the assumption of $1.7 billion in debt, with AstraZeneca then paying $3.4 billion in cash to Bristol Myers Squibb, and Amylin being folded into an existing diabetes joint venture between AstraZeneca and Bristol Myers Squibb. In the year 1999 Astra and Zeneca Group merged to form AstraZeneca (AZ). AstraZeneca’s Covid-19 vaccine AZD1222 splits experts as to whether its trials restarted too quickly on the heels of a second volunteer having a neurological event. The deal could yield up to US$500 million for the company. Shares of the British-Swedish pharmaceutical titan AstraZeneca are trading 7% lower in London today as investors price in the acquisition of Alexion Pharmaceuticals for $39 billion. The acquisition, as we discussed above, has a $13.5 billion cash component and just under $26 billion in stock. 2009), applying New York's faithless servant doctrine, the court held that a company's employee who had engaged in financial misdeeds and sexual harassment must "forfeit all of his salary and bonuses for the period of disloyalty. The British drugmaker on Saturday announced it is … The company was founded in 1999 through the merger of the Swedish Astra AB and the British Zeneca Group[6][7] (itself formed by the demerger of the pharmaceutical operations of Imperial Chemical Industries in 1993). Pascal Soriot. UK minister answers", "Covid-19: Oxford University vaccine is highly effective", "India approves AstraZeneca's COVID-19 vaccine", "EMA recommends COVID-19 Vaccine AstraZeneca for authorisation in the EU Share", "European countries suspend AstraZeneca vaccinations despite advice from EU medicines regulator", "A comprehensive list of AstraZeneca's subsidiary holdings", "AstraZeneca - MedImmune completes acquisition of Definiens", "AstraZeneca - AstraZeneca to acquire Pearl Therapeutics to strengthen respiratory portfolio", "AstraZeneca - AstraZeneca to acquire Omthera Pharmaceuticals including NDA-ready novel dyslipidemia treatment to complement cardiovascular portfolio", "Nowe inwestycje w B+R w Polsce po spotkaniu Premiera Morawieckiego z Prezesem AstraZeneca podczas Światowego Forum Ekonomicznego w Davos", "AstraZeneca immune system drug wins orphan status in rare cancer", AstraZeneca boss David Brennan quits under pressure from investors, "Astra Zeneca appoints Roches Pascal Soriot as new chief", Pharmaceutical Giant AstraZeneca to Pay $520 Million for Off-label Drug Marketing, "Drugmaker settles lawsuits over Seroquel", Astra hauls ex-CEO Lars Bildman into court, "Astra Boss Hit With $7M Fine for Sex Harassment; Reps Share Memories of Bonkers CEO", "The deadly corruption of clinical trials", "U of M Board of Regents Markingson Letter", AstraZeneca agrees to pay £505m to settle UK tax dispute, Pharmaceutical and biotechnology industry in the United Kingdom, European Directorate for the Quality of Medicines, Medicines and Healthcare products Regulatory Agency, National Collaborating Centre for Mental Health, Pharmaceutical Society of Northern Ireland, Association of the British Pharmaceutical Industry, European Federation of Pharmaceutical Industries and Associations, Royal Pharmaceutical Society of Great Britain, European and Developing Countries Clinical Trials Partnership, List of world's largest pharmaceutical companies, Pharmaceutical Services Negotiating Committee, List of companies based in the Philadelphia area, Pennsylvania Real Estate Investment Trust, https://en.wikipedia.org/w/index.php?title=AstraZeneca&oldid=1013076005, Biotechnology companies established in 1999, Pharmaceutical companies established in 1999, Multinational companies headquartered in Sweden, Multinational companies headquartered in England, Biotechnology companies of the United Kingdom, Companies related to the Wallenberg family, Companies listed on the London Stock Exchange, Companies formerly listed on the New York Stock Exchange, Companies in the Nasdaq Next Generation 100, Articles with dead external links from June 2014, Official website different in Wikidata and Wikipedia, Wikipedia articles with SUDOC identifiers, Wikipedia articles with WORLDCATID identifiers, Creative Commons Attribution-ShareAlike License, This page was last edited on 19 March 2021, at 21:57. They compared 20 and 40 mg Nexium with 20 mg Prilosec. The acquisition is expected to advance Lydall’s engineered materials offerings in new markets with similar technologies utilized in the performance materials business. AstraZeneca is an equal opportunity employers and we encourage diversity in the workplace. [49] In July 2015, Genzyme announced it would acquire the rare cancer drug Caprelsa (vandetanib) from AstraZeneca for up to US$300 million. [11], In 2002, its drug Iressa (gefitinib) was approved in Japan as monotherapy for non-small cell lung cancer. AstraZeneca: Mergers And Acquisitions From A To Z AstraZeneca Pharmaceuticals LP has been working on integrating the disparate IT systems by using a three-pronged strategy: standardizing desktops, outsourcing infrastructure, and improving its standing as an E-business. Sources insist the rumours are not true - and such a deal would certainly jar with Gilead’s deal strategy of agreeing partnerships and smaller acquisitions. [31][32] It also announced that it would focus on three therapeutic areas: Respiratory Inflammation & Autoimmunity, Cardiovascular & Metabolic Disease, and Oncology. It has also divested 11 assets. However, it continues to focus on developing its pipeline, and could be in a good position to meet … includes any. The AstraZeneca logo is seen with a hand holding a syringe and needle in this photo illustration in Warsaw, Poland on March 1, 2021. The companies had been meeting since January 2014. The company also began a Phase I/II trial collaboration with Pharmacyclics and Janssen Biotech investigating combination treatments. [100] In August 2012, Pascal Soriot was named CEO of AstraZeneca. Sources insist the rumours are not true - and such a deal would certainly jar with Gilead’s deal strategy of agreeing partnerships and smaller acquisitions. It is the biggest deal in AstraZeneca’s history and will be the largest acquisition in pharmaceuticals since AbbVie bought Allergan for more than US$63bn in 2019. [10] In 1999, AstraZeneca identified a new location for the company's US base, the "Fairfax-plus" site in North Wilmington, Delaware. www.astrazeneca.com. AstraZeneca has long been a leader in treatments for respiratory disease, but sales have stagnated. Main office on AstraZeneca's campus in Waltham, Massachusetts. The second of two deals is an agreement to study a combination treatment of MEDI4736 and Innate Pharma's Phase II anti-NKG2A antibody IPH2201 for up to US$1.275 billion. Institutional investors in Alexion had grown unhappy with that company’s own acquisition history. This is not the first major acquisition by AstraZeneca, who has accumulated an extensive acquisition history over the years, including Cambridge Antibody Technology, MedImmune, Spirogen and Definiens. RedHill Biopharma Ltd, a specialty biopharmaceutical company focused on gastrointestinal diseases, today announced that it has completed the recently announced acquisition of the global rights, excluding Europe, Canada and Israel, to Movantik ® (naloxegol), for the treatment of opioid-induced constipation (OIC) from AstraZeneca. Alexion would pay AstraZeneca a fee of up to $1.2 billion if it completes a deal with another buyer. For a glimpse of what may lie ahead for AstraZeneca should Pfizer succeed in its takeover bid, look no further than the US pharmaceutical group's recent history of major acquisitions. If approved by shareholders, … INO-3112 targets Human papillomavirus types 16 and 18. [47] In late June the company announced it has entered into a partnership agreement with Eolas Therapeutics on the Eolas Orexin-1 Receptor Antagonist (EORA) program for smoking cessation and other treatments. Cambridge-based AstraZeneca, which is developing a coronavirus vaccine with the University of Oxford, said on Saturday the acquisition of Alexion Pharmaceuticals had been given the green-light by directors, but still needs shareholder and regulatory approval. The companies have been talking for several months, said AstraZeneca Chief Executive Pascal Soriot. [104] In March 2001, the company began to market Nexium, as it would a brand new drug. AstraZeneca plc (/ ˌ æ s t r ə ˈ z ɛ n ə k ə ... Acquisition history. AstraZeneca’s largest acquisition to date was in 2007, when it acquired MedImmune for … A major criterion governing the drugs approval was, on average, its ability to shrink tumours in patients for 7.9 months. Acquisition Overview - AstraZeneca Investor Presentation The acquisition comes with a 45% premium for a price of $175 / share net versus ~$120 / share currently. Grünenthal Chief Executive Officer Gabriel Baertschi said the acquisition of the two AstraZeneca drugs is the largest single investment in the history of the company. [98], As of 2008, David Brennan was paid US$1,574,144 for his role as chief executive officer. [100], In April 2010, AstraZeneca settled a qui tam lawsuit brought by Stefan P. Kruszewski for US$520 million to settle allegations that the company defrauded Medicare, Medicaid, and other government-funded health care programs in connection with its marketing and promotional practices for the blockbuster atypical antipsychotic, Seroquel. [87], In January 2021, India approved the use of the Oxford–AstraZeneca vaccine, paving the way for a mass immunisation campaign in the world's second most populous country. [63], In March 2019, AstraZeneca announced it will pay up to US$6.9 billion to work with Daiichi Sankyo Co Ltd on an experimental treatment for breast cancer. [34], On 19 May 2014 AstraZeneca rejected a "final offer" from Pfizer of £55 per share, which valued the company at £69.4 billion (US$117 billion). 17 December 2015. [67][68], In February 2020, AstraZeneca agreed to sublicense its global rights (except Europe, Canada and Israel) to the drug Movantik, to Redhill Biopharma. Every day, new opportunities emerge around M&A and we help professionals of all types comb through transactions, investors, and corporate acquirers via an easy-to-use web database that is accessible to anyone. [106] While omeprazole is approved only at doses of up to 20 mg for the treatment of gastroesophageal reflux,[107] esomeprazole is approved for doses up to 40 mg.[108], In 2007, Marcia Angell, former editor-in-chief of the New England Journal of Medicine and a lecturer in social medicine at the Harvard Medical School, said in Stern, a German-language weekly newsmagazine, that AstraZeneca's scientists had misrepresented their research on the drug's efficiency, saying "Instead of using presumably comparable doses [of each drug], the company's scientists used Nexium in higher dosages. [102], In March 2011, AstraZeneca settled a lawsuit in the United States totalling US$68.5 million to be divided up to 38 states. [42] The company also announced its plan to spend US$40 million creating a new subsidiary focused on small molecule anti-infectives – primarily in the research of the gyrase inhibitor, AZD0914, which is currently in Phase II for the treatment of gonorrhea. The prospects for the AstraZeneca share price on a long-term basis may not have changed as much as its recent stock price performance suggests. AstraZeneca approaches Gilead about potential merger: report", "AstraZeneca Approaches Gilead About Potential Merger", "Astrazeneca 'drops interest' in Gilead Sciences", "AstraZeneca bets up to $6 billion on new Daiichi cancer drug", "AstraZeneca acquires oral PCSK9 inhibitor programme from Dogma Therapeutics", "AstraZeneca to acquire Alexion in $39 billion deal", "AstraZeneca to Acquire Alexion, Accelerating the Company's Strategic and Financial Development | Alexion Pharmaceuticals, Inc", "Oxford vaccine researchers have found 'winning formula', AstraZeneca chief says", "Is good news for India on the vaccine front here? British pharmaceutical giant AstraZeneca Plc (LON: AZN) has announced one of its largest acquisitions in history. If the takeover had proceeded, Pfizer would have become the world's biggest drug maker. "[109], On 4 February 1998, Astra USA sued Lars Bildman, its former president and chief executive officer, seeking US$15 million for defrauding the company. [90], The following is an illustration of the company's major mergers and acquisitions and historical predecessors:[91], AstraZeneca develops, manufactures and sells pharmaceutical and biotechnology products to treat disorders in the oncology, cardiovascular, gastrointestinal, infection, neuroscience, respiratory and inflammation areas. The British drugmaker on Saturday announced it is … LONDON/NEW YORK (Reuters Breakingviews) - The largest acquisition in AstraZeneca’s history is bold as well as big. [82] The company also announced plans for a clinical trial to assess the potential use of Calquence in the treatment of COVID-19. Why AstraZeneca's $39bn swoop is proving hard for some to swallow. Acquirer Name . The following is an illustration of the company's major mergers and acquisitions and historical predecessors: AstraZeneca. [72], In July 2020, the business entered into its second collaboration with Daiichi Sankyo, centred around the development of DS-1062, an antibody drug conjugate. AstraZeneca acquires the respiratory division of Takeda Pharmaceutical. The acquisition will enable AstraZeneca to strengthen its position in immunology. [9] In 1993 the British chemicals company ICI (established from four British chemical companies) demerged its pharmaceuticals businesses and its agrochemicals and specialities businesses, to form Zeneca Group PLC. The largest deal in AstraZeneca’s history has the market concerned that the company is paying too much for Alexion, even as analysts have praised the … LONDON/NEW YORK (Reuters Breakingviews) - The largest acquisition in AstraZeneca’s history is bold as well as big. Newer drugs for cancer and diabetes have kept the business growing, but competition remains very stiff in both those areas. 21 March 2013, Lemke TL, Williams DA, Roche VF, Zito SW. Foye's Principles of Medicinal Chemistry, 7th edition, Chapter 12, National Institute of Allergy and Infectious Diseases, Pharmaceutical industry in the United Kingdom, "AstraZeneca > GC Powerlist: Sweden Teams 2019", "UK "will be able to get out of this by the spring," minister says after regulator approves AstraZeneca vaccine", "AstraZeneca's COVID-19 vaccine gets the green light in the UK", "Registered office and corporate headquarters", "UPDATED: AstraZeneca to ax 1,600, relocate thousands in global R&D reshuffle", "AstraZeneca Selects Wilmington, Del. The drugmaker will fund the acquisition with a $17.5 billion financing facility from Morgan Stanley, JPMorgan Chase & Co. and Goldman Sachs Group Inc. Astra AB was founded in 1913 in Södertälje, Sweden, by 400 doctors and apothecaries. According to the settlement agreement, AstraZeneca targeted its illegal marketing of the anti-psychotic Seroquel towards doctors who do not typically treat schizophrenia or bipolar disorder, such as physicians who treat the elderly, primary care physicians, pediatric and adolescent physicians, and in long-term care facilities and prisons. Our values guide our decision making, define our beliefs and foster a strong AstraZeneca culture. [70][71] However, these plans were subsequently dropped because it would have distracted the company from its own pipeline and ongoing COVID-19 vaccine efforts. [86] The researchers thought that the figure may be as high as 90% by tweaking the dose. [29][30] That announcement included the announcement that it would cut 1,600 jobs; three days later it announced it would cut an additional 2,300 jobs. Save Search . [83], In June 2020, the National Institute of Allergy and Infectious Diseases (NIAID) confirmed that the third phase of testing for potential vaccines developed by Oxford University and AstraZeneca would begin in July 2020. [48] In July the company announced it would sell off its rights to Entocort (budesonide) to Tillotts Pharma for US$215 million. [81], In April 2020, Chief Executive Pascal Soriot, reported that the company was working with GlaxoSmithKline and the University of Cambridge to develop a new laboratory capable of conducting 30,000 COVID-19 tests per day. A report that U.K. drugmaker AstraZeneca PLC considered Gilead Sciences Inc. an acquisition target has spurred speculation that M&A activity could be making a comeback in the pharmaceutical sector after a pandemic slowdown.. This was in a last-ditch effort to distract attention from the real wrongdoer, Bildman himself." Ezogelin Oflazoglu-Gruyters. The Company’s most targeted sectors include life science (86%) and information technology (8%). AstraZeneca PLC (NASDAQ:AZN) AstraZeneca to acquire Alexion Conference Call December 12, 2020 9:00 AM ET. [73], In September 2020, AstraZeneca announced it had acquired the preclinical oral PCSK9 inhibitor programme from Dogma Therapeutics for an undisclosed sum. [75] Upon completion of merger, Alexion shareholders will own approximately 15% of combined company. The deal, the largest in AstraZeneca’s history, is expected to close in the third quarter of 2021. The acquisition will enable AstraZeneca to strengthen its position in immunology. AstraZeneca’s largest acquisition to date was in 2007, when it acquired MedImmune for $15.6B. With the cards having been marked in that way, Nexium looked like an improvement – which however was only small and shown in only two of the three studies. [40], In February, the company announced it would acquire the US and Canadian rights to Actavis's branded respiratory drug business for an initial sum of US$600 million. [114], In 2004, University of Minnesota research participant Dan Markingson committed suicide while enrolled in an industry-sponsored pharmaceutical trial comparing three FDA-approved atypical antipsychotics: Seroquel (quetiapine), Zyprexa (olanzapine), and Risperdal (risperidone).
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